Drug Discovery &. Chemical Biology
Welcome to the Bing Xiong's Lab from Shanghai Institute of Materia Medica, CAS! We are a dynamic research group dedicated to drug discovery by integrating multiple displines of organic chemistry, structural biology and computational drug design. Our work at the intersection of chemistry and biology aims to develop small molecules and peptides targeting important proteins.
We are very proud of that the drug we developed, Gumarontinib, an oral highly selective mesenchymal-epithelial transition (MET) inhibitor and a Category 1 innovative new chemical drug, for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with MET exon 14 skipping mutation got conditionally approval on March 8, 2023, by the National Medical Products Administration (NMPA) of China. In June, 2024, it was also approved by the Japanese Ministry of Health, Labour and Welfare.
If you are interested in our research or would like to collaborate, please feel free to contact us:
Email: bxiong at simm.ac.cn
Phone: +86 21-68077888
Address: 555 Zuchongzhi Road, Pudong District, Shanghai, P.R. China